Once my sister busted a nut watching a headliner I worked with. He closed his set by miming the insertion of a tampon up his asshole. I don't recall the exact joke. After his set my sister made a beeline for him, running roughshod over the other more delicate comedy groupies. She gushed about his tampon bit and then told him he should get an actual tampon and really stick it up there. And then she laughed like crazy. I thought it was a good note.